Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways
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چکیده
منابع مشابه
Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways.
Virulence of Pseudomonas aeruginosa involves the co-ordinate expression of a range of factors including type IV pili (tfp), the type III secretion system (TTSS) and quorum sensing. Tfp are required for twitching motility, efficient biofilm formation, and for adhesion and type III secretion (TTS)-mediated damage to mammalian cells. We describe a novel gene (fimL) that is required for tfp biogene...
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متن کاملLigand responses of Vfr , the virulence factor regulator from Pseudomonas 1 aeruginosa 2 3
Jose Serate 1 , Gary P. Roberts 1 , Otto Berg 2 and Hwan Youn 3,* 4 5 Departments of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706 6 Department of Chemistry, California State University at Fresno, Fresno, California 93740 7 Department of Biology, California State University at Fresno, Fresno, California 93740 8 9 10 Running title: ligand response of Vfr 11 12 13 14 15 ...
متن کاملLigand responses of Vfr, the virulence factor regulator from Pseudomonas aeruginosa.
Vfr, a transcription factor homologous to the Escherichia coli cyclic AMP (cAMP) receptor protein (CRP), regulates many aspects of virulence in Pseudomonas aeruginosa. Vfr, like CRP, binds to cAMP and then recognizes its target DNA and activates transcription. Here we report that Vfr has important functional differences from CRP in terms of ligand sensing and response. First, Vfr has a signific...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2005
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2005.04479.x